Welcome to the Spoel Lab

Our lab explores the mechanisms by which multicellular organisms reprogram gene expression in response to changes in their environment, a skill that is vital for cells and organisms to survive.

  • Publications
  • Group members
  • Opportunities

  • Latest News

    Ubiquitin chain length determines activity of gene expression activators

    The Spoel Research Group publishes a paper in eLIFE reporting a new mechanism by which gene expression activators may be regulated. Activator modification by ubiquitin chains of dynamic length is shown to underpin functional gene expression responses during onset of plant immunity.


    BBSRC Discovery Fellowship awarded to Lucas Frungillo

    Dr. Lucas Frungillo wins a prestigious BBSRC Discovery Fellowship. The fellowship, worth £300K, provides support for researchers to undertake independent research and gain leadership skills. The fellowship will be hosted by the Spoel Group.


    Cellular trash bins show a surprising activity that controls plant immunity

    The Spoel Research Group publishes a paper in PLoS Pathogens showing that plant proteasomes, which function to degrade proteins, contain an unexpected activity that is required for appropriate activation of plant immune responses.


    "No-deal" is a bad deal for science

    Dr. Steven Spoel worked with The Royal Society to produce a Brexit no-deal factsheet. The data indicate that if the UK leaves the EU without a deal, it will impact on scientific research immediately and could take years to recover from. The factsheet explains why leaving the EU with "no-deal" is detrimental to science.


    GARNet report on plant science funding

    GARNet, a supportive network for the fundamental UK plant science community, publishes a report on BBSRC funding for plant science. The report brings to light unexpected funding trends that led GARNet to make recommendations to the BBSRC and the community.


    Report published on GARNet- and SEB- organised conference

    The SEB publishes a meeting report by Dr. Lucas Frungillo from the Spoel Research Group. The article summarises the cutting-edge science presented at a recent international conference held in Edinburgh on the role of post-translational modifications in shaping plant phenotypes.

    JCSCell Scientists to Watch

    The Journal of Cell Science publishes an interview with Steven Spoel. The interview discusses career progression, past and current science in the Spoel Research Group and future challenges that are being addressed.

    SEB-GARNet conference

    GARNet-SEB conference on importance of post-translational modifications

    GARNet and SEB joined forces to deliver the first conference on the functional roles of diverse post-translational modifications in plant biology. Conference delegates gathered for three days in the beautiful city of Edinburgh to discuss advances and to gain hands-on training in a workshop.

    Mol Cell Preview

    New editorial preview in Molecular Cell on "Modulating the Modulator"

    The Spoel Research Group writes an editorial preview in Molecular Cell that discusses an important new publication from the Prof. Jianru Zuo's group at the Chinese Academy of Science in Beijing. The commentary discusses their findings on how nitric oxide signalling controls protein methylation during responses to abiotic stress.

    PNAS article

    Enzyme discovered that protects cellular anti-oxidants from damage

    The Spoel Research Group publishes a new article in PNAS describing the discovery of an enzyme that protects cellular antioxidants from becoming damaged. This finding has potential wide-ranging implications from agricultural to biomedical healthy ageing research. Discussed on the GARNet YouTube channel!!

    The Scientist magazine

    Magazine The Scientist publishes article on international collaborations

    Magazine The Scientist publishes an article about how scientists are concerned about future international collaboration. In an interview with Dr. Abby Olena, a science writer, Dr.Steven Spoel and other scientists provide their personal views on international collaboration and mobility.

    International mobility

    Royal Society international mobility study published

    The Royal Society publishes its research on international mobility, providing an understanding of how, where and why researchers move to and from the UK. Dr. Steven Spoel provides his personal perspective on international mobility in one of ten case studies.

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