Wang Z, Orosa-Puente B, Spoel SH (2022) Analysis of Proteasome-Associated Ubiquitin Ligase Activity.. Methods Mol Biol 2581:57-67.

Wang Z, Orosa-Puente B, Nomoto M, Grey H, Potuschak T, Matsuura T, Mori IC, Tada Y, Genschik P, Spoel SH (2022) Proteasome-associated ubiquitin ligase relays target plant hormone-specific transcriptional activators.
SCIENCE ADVANCES 8(42): eabn4466.

Orosa-Puente B, Spoel SH (2022) Harnessing the ubiquitin code to respond to environmental cues. ESSAYS BIOCHEM 66: 111-121.

Wang Z, Spoel SH. Essays (2022) HECT ubiquitin ligases as accessory proteins of the plant proteasome. ESSAYS BIOCHEM 66: 135-145.

Matsumura M, Nomoto M, Itaya T, Aratani Y, Iwamoto M, Matsuura T, Hayashi Y, Mori T, Skelly MJ, Yamamoto YY, Kinoshita T, Mori IC, Suzuki T, Betsuyaku S, Spoel SH, Toyota M, Tada Y (2022) Mechanosensory trichome cells evoke a mechanical stimuli-induced immune response in Arabidopsis thaliana. NATURE COMMUNICATIONS 13: 1216.

Nomoto M, Skelly MJ, Itaya T, Mori T, Suzuki T, Matsushita T, Tokizawa M, Kuwata K, Mori H, Yamamoto YY, Higashiyama T, Tsukagoshi H, Spoel SH, Tada Y (2021) Suppression of MYC transcription activators by the immune cofactor NPR1 fine-tunes plant immune responses. Cell Reports 37: 110125.

Skelly MJ, Spoel SH (2021) Characterising Plant Deubiquitinases with in vitro Activity-based Labelling and Ubiquitin Chain Disassembly Assays.
BIO PROTOC 11: e4015.

Pardal AJ, Piquerez SJM, Dominguez-Ferreras A, Frungillo L, Mastorakis E, Reilly E, Latrasse D, Concia L, Gimenez-Ibanez S, Spoel SH, Benhamed M, Ntoukakis V (2021) Immunity onset alters plant chromatin and utilizes EDA16 to regulate oxidative homeostasis.
PLoS PATHOG 17: e1009572.

Skelly MJ, Furniss JJ, Grey HL, Wong KW, Spoel SH (2019) Dynamic ubiquitination determines transcriptional activity of the plant immune coactivator NPR1.  eLIFE 8: e47005.

Skelly MJ, Malik SI, Le Bihan T, Bo Y, Jiang J, Spoel SH, Loake GJ (2019) A role for S-nitrosylation of the SUMO-conjugating enzyme SCE1 in plant immunity
PROC. NATL. ACAD. SCI. USA (PNAS) 116: 17090-17095.

ChenJ, Mohan R, Zhang Y, Li M, Chen H, Palmer IA, Chang M, Qi G, Spoel SH, Mengiste T, Wang D, Liu F, Fu ZQ. NPR1 promotes its own and target gene expression in plant defense by recruiting CDK8. Plant Physiol. 181: 289-304.

Spoel SH (2019) Signal Transduction in Plant Immunity. Plant Cell 31: 1412-1413 (PDF).

Mata-Pérez C, Spoel SH (2019) Thioredoxin-mediated redox signalling in plant immunity.
PLANT SCIENCE 279: 27-33.

Furniss JJ, Grey H, Wang Z, Nomoto M, Jackson L, Tada Y, Spoel SH (2018) Proteasome-associated HECT-type ubiquitin ligase activity is required for plant immunity. PLoS Pathog. 14: e1007447 (PDF).

Spoel SH (2018) Orchestrating the proteome with post-translational modifications. J. Exp. Bot. 69: 4499-4503 (PDF).

Adams EHG, Spoel SH (2018) The Ubiquitin-proteasome System as a Regulator of Plant Immunity. J. Exp. Bot. 69: 4529-4537 (PDF).

Mata-Pérez C, Spoel SH (2018) Thioredoxin-mediated redox signalling in plant immunity.
PLANT SCI. 279: 27-33 (PDF).

Kneeshaw S, Spoel SH (2018) Thioredoxin-dependent decomposition of protein S-nitrosothiols. METHODS MOL. BIOL. 1747: 281-297 (PDF).

Dussart F, Douglas R, Sjökvist E, Hoebe PN, Spoel SH, McGrann GRD (2018) Genome-based discovery of polyketide-derived secondary metabolism pathways in the barley pathogen Ramularia collo-cygni. MOL. PLANT MICROBE INTERACT. 31: 962-975 (PDF).

Frungillo L, Spoel SH (2017) Modulating the modulator: regulation of protein methylation by nitric oxide. MOLECULAR CELL 67: 535-537 (PDF).

Kneeshaw S, Keyani R, Delorme-Hinoux V, Imrie L, Loake GJ, Le Bihan T, Reichheld J-P, Spoel SH (2017) Nucleoredoxin Guards against Oxidative Stress by Protecting Antioxidant Enzymes. PROC. NATL. ACAD. SCI. USA (PNAS) 114: 8414-8419 (PDF).

Skelly MJ, Frungillo L, Spoel SH (2016) Transcriptional regulation by complex interplay between post-translational modifications. CURRENT OPINION IN PLANT BIOLOGY 33: 126-132 (PDF).

Frungillo L, Spoel SH, Salgado I (2016) Chapter Four - Control of Nitrogen Assimilation in Plants through S-nitrosothiols, In: ADVANCES IN BOTANICAL RESEARCH 77: 55-78 (PDF). Edited by David Wendehenne, ISSN 0065-2296, ISBN 9780128010747.

Yun BW, Skelly MJ, Yin M, Yu M, Mun BG, Lee SU, Hussain A, Spoel SH, Loake GJ (2016) Nitric oxide and S-nitrosoglutathione function additively during plant immunity. NEW PHYTOLOGIST 211: 516-526.

Furniss JJ and Spoel SH (2015) Cullin-RING ubiquitin ligases in salicylic acid-mediated plant immune signaling. FRONTIERS IN PLANT SCIENCE 6:154 (PDF).

Choudhury NR, Nowak JS, Zuo J, Rappsilber J, Spoel SH, Michlewski G (2014) Trim25 is an RNA-specific activator of Lin28a/TuT4-mediated uridylation. CELL REPORTS 9: 1265–1272.

Frungillo L, Skelly MJ, Loake GJ, Spoel SH*, Salgado I* (2014) S-nitrosothiols regulate nitric oxide production and storage in plants through the nitrogen assimilation pathway. NATURE COMMUNICATIONS 5: 5401. doi:10.1038/ncomms6401 (Open Access PMC).
(* Co-corresponding authors)

Kneeshaw S, Gelineau S, Tada Y, Loake GJ, Spoel SH (2014) Selective protein denitrosylase activity of Thioredoxin-h5 modulates plant immunity. MOLECULAR CELL 56: 153-162.

Yu M, Lamattina L, Spoel SH, Loake GJ (2014) Nitric oxide function in plant biology: a redox cue in deconvolution. NEW PHYTOLOGIST 202: 1142-1156.

Spoel S and Van Ooijen G (2014) Circadian redox signalling in plant immunity and abiotic stress. ANTIOXIDANTS & REDOX SIGNALLING 20: 3024-39 (PDF).

De Wit M, Spoel SH, Sanchez-Perez GF, Gommers CMM, Pieterse CMJ, Voesenek LACJ, Pierik R (2013) Perception of low Red:Far-red ratio compromises both salicylic acid- and jasmonic acid-dependent pathogen defences in Arabidopsis. PLANT JOURNAL 75: 90-103.

Fu ZQ, Yan S, Saleh A, Wang W, Ruble J, Oka N, Mohan R, Spoel SH, Tada Y, Zheng N, Dong X (2012) NPR3 and NPR4 are receptors for the immune signal salicylic acid in plants. NATURE 486: 228-232.

Spoel SH and Dong X (2012) How do plants achieve immunity? Defence without specialized immune cells. NATURE REVIEWS IMMUNOLOGY 12: 89-100.

Yun BW, Spoel SH, Loake GJ (2012). Synthesis and signalling by small, redox active molecules in the plant immune response. BIOCHIM. BIOPHYS. ACTA 1820: 770-776.

Yun BW, Feechan A, Yin M, Saidi NBB, Le Bihan T, Yu M, Moore JW, Kang JG, Kwon E, Spoel SH, Pallas JA, Loake GJ (2011) S-nitrosylation of NADPH oxidase regulates cell death in plant immunity. NATURE 478: 264-268.

Moore JW, Loake GJ, Spoel SH (2011) Transcription dynamics in plant immunity. PLANT CELL 28: 2809-2820 (PDF).

Spoel SH and Loake GJ (2011) Redox-based protein modifications: the missing link in plant immune sigalling. CURRENT OPINION IN PLANT BIOLOGY 14: 358-364.

Spoel SH, Tada Y, Loake GJ (2010) Post-translational protein modification as a tool for transcription reprogramming. NEW PHYTOLOGIST 186: 333-339 (PDF).

Spoel SH, Mou Z, Tada Y, Spivey NW, Genschik P, Dong X (2009) Proteasome-mediated turnover of the transcription co-activator NPR1 plays dual roles in regulating plant immunity. CELL 137: 860-872 (PDF & Supplement).

Leon-Reyes A, Spoel SH, De Lange ES, Abe H, Kobayashi M, Tsuda S, Millenaar FF, Welschen RAM, Ritsema T, Pieterse CMJ (2009) Ethylene modulates the role of NONEXPRESSOR OF PATHOGENESIS-RELATED GENES1 in cross-talk between salicylate and jasmonate signaling in Arabidopsis. PLANT PHYSIOL 149: 1797-1809 (PDF).

Tada Y, Spoel SH, Pajerowska-Mukhtar K, Mou Z, Song J, Wang C, Zuo J, and Dong X (2008) Plant immunity requires conformational changes of NPR1 via S-nitrosylation and thioredoxins, SCIENCE 321: 952-956 (PDF & Supplement).

Spoel SH and Dong X (2008) Making sense of hormone crosstalk during plant immune response. CELL HOST & MICROBE 3: 348-351 (PDF).

Spoel SH, Johnson JS, and Dong X (2007) Regulation of tradeoffs between plant defenses against pathogens with different lifestyles. PROC. NATL. ACAD. SCI. USA (PNAS) 104: 18842-18847 (PDF).

Beckers GJM and Spoel SH (2006) Fine-tuning plant defence signalling: salicylate versus jasmonate. PLANT BIOLOGY 8: 1-10.

Spoel SH et al. (2003) NPR1 modulates cross-talk between salicylate- and jasmonate-dependent defense pathways through a novel function in the cytosol. PLANT CELL 15: 760-770 (PDF) .





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